Advantages of particle therapy

At the Marburg Ion Beam Therapy Center (MIT), irradiation takes place with protons or carbon ions (12C ions). Both forms of irradiation cause DNA damage to the tumor cells in the target area. Only if this damage can no longer be repaired by the cells does it lead to cell death and thus to the death of the tumor.

With the special physical properties of particle radiation (so-called Bragg peak), a better sparing of the surrounding tissue can be achieved with the same dose compared to photon irradiation. In some cases, a higher radiation dose may even be achieved.

The extent of DNA damage is largely dependent on the radiation dose.

Since carbon ions cause significantly more severe DNA damage than protons and photons, they are used for particularly radiation-resistant tumor types.

Particle therapy has a particular advantage in children, as long-term side effects such as growth and development deficits can be avoided by sparing the organs at risk. In addition, particle therapy can be used to reduce the radiation dose which may contribute to lowering the rate of secondary malignancies.

Biological advantages of heavy ion radiation

Physical advantages of proton and heavy ion radiation